An antagonist of 5-hydroxytryptamine receptors with high selectivity selectivity has antiemetic activity.
Prevention and treatment of nausea and vomiting associated with cytostatic therapy means inhibits cell division.
Inside typically assigned by 2 times 1 tablet per day for the cytostatic therapy. The first dose is administered no sooner than 1 for 1 hour before cytostatic therapy `th. The maximum daily dose should not exceed 9 mg.
For intravenous administration of 3 mg of drug dissolved in 20-50 ml of sterile infusion solution isotonic sodium chloride solution, 5% glucose solution, Hartmann solution of sodium lactate or 10% mannitol solution and injected within 5 min. It is recommended to prepare the solution immediately before administration, but after dilution in sterile aseptic infusion solution can be used within 24 hours after the deadline application ready solution is not recommended. Using other solutions are not allowed.
For the prevention of nausea and vomiting drug is administered once a day in some cases it is possible to hold two additional injection per day. Duration of the course of preventive treatment can be up to 5 consecutive days; granisetron treatment should be completed before the start of treatment with cytostatics. For therapeutic purposes, the drug is administered in the same dose as for prevention. Undertake additional infusions allowed at intervals of not less than 10 min. The maximum daily dose -9 mg three 5-minute infusion of 3 mg.
Any changes in dosing of the drug in elderly patients is not required.
Granisetron infusion solution is not recommended to mix with other drugs.
Possible transient increase in liver transaminase enzymes in the blood, constipation; headache; skin rash.
Due to the fact that granisetron may reduce peristalsis wavelike motion of the lower intestine, patients with signs of partial bowel obstruction after drug administration should be under medical supervision.
Increased chuvstitelnost to the drug.
In the absence of evidence of life is not recommended to prescribe a drug for pregnant women. Strict indications perhaps his appointment lactating women, but in this case, you should stop breast-feeding during treatment drug.
Tablets 0.001 g; concentrate for infusion vials of 3 ml of 0.003 g of the drug in a package of 5 pieces.
Currently, insufficient data on safety and efficacy of the drug in children.
List B. Store at temperatures below +30 ° C and protected from light, do not freeze. Granisetron solution can be stored for more than 24 hours at room temperature and normal for indoor lighting should not be exposed to direct sunlight.
Before using the medication Granisetron , you should consult your doctor. This operating instruction is given a free transfer and is intended solely for information. For more information, please contact the manufacturer annotations.